Determination of left ventricular mass in man using single photon emission computed tomography

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6779379

Wolfe, C L; Jansen, D E; Corbett, J R; Willerson, J T; Lipscomb, K; Redish, G; Filipchuk, N; Gabliani, G; Lewis, S E

The measurement of viable left ventricular (LV) mass may have important prognostic significance in patients with ischemic heart disease or hypertrophic heart disease. To test the hypothesis that single photon emission computed tomography (SPECT) could accurately determine LV mass in man, the authors compared SPECT measurements of LV mass to LV mas determined by cineangiography in 12 patients with normal coronary arteries and normal LV functions. Repeat SPECT determinations of LV mass were carried out in 5 patients. Each patient was injected with 2 to 2.4 mCi of thallium (T1)-201 in the resting state. Projection images (64x64) containing a minimum of 80,000 counts were acquired at 6-degree intervals over 180-degrees using a rotating gamma camera. Transverse sections were reconstructed by filtered backprojection. The boundary of LV uptake of T1-201 in each transverse section was defined using a simple three-dimensional threshold detector. The total number of voxels demonstrating LV T1-201 uptake was multiplied by the voxel volume and the specific gravity of myocardium (1.05g/cc). Cath determinations of LV mass were made from end diastolic frames of a biplane left ventriculogram using the method of a previous study. There was good correlation between LV mass determined by SPECT and by cineangiography. Mean cath LV mass was 207.8 +- 45.4g (S.D.). Mean SPECT LV mass was 207.4 +- 43.3 g. Linear regression analysis revealed the following relationship: SPECT LV mass = 0.78 x Cath LV mass +45.8 (r=0.82, root mean square deviation from regression = 25.1). The SPECT values of LV mass varied an average of 10.4+- 4.6 (S.D.) % in the 5 patients where two determinations were made. The authors conclude that SPECT of T1-201 can accurately measure left ventricular mass in man.

• Research Organization: Univ. of Texas Health Science Center, Dallas, TX
• OSTI ID: 6779379
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
CORONARIES
DAYS LIVING RADIOISOTOPES
DENSITY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GAMMA CAMERAS
HEART
HEAVY NUCLEI
IMAGES
INJECTION
INTAKE
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MASS
MATHEMATICS
MEDICINE
MUSCLES
MYOCARDIUM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PHYSICAL PROPERTIES
PRIMATES
RADIOISOTOPES
RADIOLOGY
REGRESSION ANALYSIS
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STATISTICS
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
UPTAKE
USES
VASCULAR DISEASES
VERTEBRATES
VOLUME