Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model

Journal Article · Tue Dec 01 04:00:00 EST 1981 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.64.6.1256· OSTI ID:5760997

Wackers, F J; Klay, J W; Laks, H; Schnitzer, J; Zaret, B L; Geha, A S

We evaluated the pathophysiologic correlates of right ventricular (RV) thallium-201 (/sup 201/Tl) visualization in three canine models: (1) acute RV pressure overload (RVPO) induced by acute constriction of the pulmonary artery; (2) acute RV volume overload (RVVO) induced by acute left-to-right atrial shunt; and (3) RV hypetrophy (RVH) induced by chronic constriction of the pulmonary artery. Thallium-201 myocardial images, RV and left ventricular (LV) /sup 201/Tl tissue accumulation and RV and LV myocardial blood flow (MBF) were compared with control measurements. In control dogs, the right ventricle was not visualized. In dogs with RVPO, RVVO, and RVH, the right ventricle was clearly visualized. In RVPO, and to a lesser degree in RVVO, RV/LV /sup 201/Tl uptake per gram tissue and RV/LV MBF per gram tissue were increased significantly compared with control, whereas in RVH, these values were not significantly different from control. However, total RV/LV /sup 201/Tl tissue uptake and total RV/LV MBF (RV/LV MBF x RV/LV mass) were not significantly different in RVPO and RVH, consistent with the similar degree of RV visualization on /sup 201/Tl images. Total RV/LV /sup 201/Tl tissue uptake correlated well with the degree of RVH (r = 0.91). However, quantitative analysis of computerized /sup 201/Tl images correlated less well (r = 0.77) with the degree of RVH. We conclude that RV visualization at rest in /sup 201/Tl images does not necessarily indicate RVH, but may be due to acutely increased RV work load. In acute RVPO, RV visualization is predominantly due to a marked increase of RV MBF per unit tissue, whereas in RVH this is predominantly due to an increase of RV mass.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT
• OSTI ID: 5760997
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 64:6; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
IMAGES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
VERTEBRATES