Radiopharmaceutical development for diagnostic and therapeutic applications

Conference · Fri Oct 31 04:00:00 EST 1986

OSTI ID:6964769

Srivastava, P C

Several radioisotopes are currently being evaluated for radiopharmaceutical development. These include the radioisotopes of iodine for developmental, therapeutic and diagnostic applications by SPECT. Other metallic radioisotopes are being developed for diagnostic and therapeutic applications. All these radioisotopes (copper-64, osmium-191, and tungsten-188) are HFIR produced, except yttrium-90, which is a by-product of uranium fission. Osmium-191 decays by isomeric transition to iridium-191m (half-life 5 sec). A bed-side Os/Ir generator has been developed which allows bolus elution of pure iridium-191m for first-pass heart studies in adults and children. Potential use of radiolabeled nucleosides as tumor localization agents is also addressed. The utility of nucleosides coupled with tumor specific antibodies for improved selectivity in immunotherapy and diagnosis of tumor should be explored. New production and purification techniques for medical radioisotopes and new versatile agents for radiolabeling antibodies for wide-spread applications should be investigated.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6964769
• Report Number(s): CONF-8610204-1; ON: DE87002624
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
COMPUTERIZED TOMOGRAPHY
COPPER 64
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 123
IODINE 125
IODINE 131
IODINE ISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OSMIUM 191
OSMIUM ISOTOPES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RHENIUM 188
RHENIUM ISOTOPES
RIBOSIDES
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STABLE ISOTOPES
THERAPEUTIC USES
TOMOGRAPHY
TUNGSTEN 188
TUNGSTEN ISOTOPES
USES
YTTRIUM 90
YTTRIUM ISOTOPES