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Liver endothelium desialates ceruloplasmin

Journal Article · · Biochem. Biophys. Res. Commun.; (United States)

Our previous work indicated that ceruloplasmin (CP) is transported through liver endothelium via a receptor-mediated mechanism and is subsequently externalized on the albuminal side. In the present work /sup 125/I or 3H-labeled ceruloplasmin was chased through the endothelium and the supernate was subjected to affinity chromatography using RCA120 column. Evidence was obtained that liver endothelium completely desialates CP in the course of its transport. The results substantiated the view that desialated CP is subsequently removed by hepatocytes through asialoglycoprotein receptors.

Research Organization:
Univ. of Mississippi School of Medicine, Jackson
OSTI ID:
6963804
Journal Information:
Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 1; ISSN BBRCA
Country of Publication:
United States
Language:
English