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Elimination of an accessory population involved in proliferation of pleuripotent hematopoietic stem cells from bone marrow by mouse antibrain serum

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6958331
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The authors study changes in the number of splenic exocolonies and also postradiation repopulation of hematopoietic organs in recipients after receiving an injection of bone marrow treated with mouse antibrain serum (MABS), with or without the addition of thymocytes in the later stages. The recipient mice were irradiated with /sup 60/Co gamma rays in a dose of 8.5-8.0 Gy, on the Luch-1 radiotherapeutic apparatus 18 h before receiving the injection of bone marrow and thymocytes. It is postulated that MABS inactivates a population of cells in the bone marrow which are invloved in the control of colony-forming-units (CFUs) proliferation. This population is restored in the animal by the 14th day after irradiation and of injection of MABS-treated bone marrow.
Research Organization:
Res Institute of Medical Radiology, Ministry of Health, Moscow
OSTI ID:
6958331
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:11; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550301* -- Cytology-- Tracer Techniques
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BLOOD SERUM
BODY
BONE MARROW
CELL PROLIFERATION
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SPLEEN COLONY FORMATION
STEM CELLS
THERAPY
THYMOCYTES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES