Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19880701)62:1<58::AID-CNCR2820620113>3.0.CO;2-R· OSTI ID:6953480

Wargotz, E S; Sidawy, M K; Jannotta, F S

The occurrence of a glioblastoma with sarcoma, a gliosarcoma, in the left frontal-temporal area of a 49-year-old woman with a history of Thorotrast exposure, is described. Thorotrast-laden histiocytes and free Thorotrast material were found in both components of the tumor. An overlying, adherent dural cranial lesion was found to contain massive deposits of Thorotrast embedded in a dense fibrotic and sclerotic stroma with focal calcification. These features are typical of Thorotrastoma. Thorotrast stains greenish-brown with hematoxylin and eosin and appears as refractile granular particles of relatively uniform size either within histiocytes or as free material. The radioactivity of the deposits was confirmed through the use of a scintillation counter, and thorium 232 was definitively identified though the use of scanning electron microscopy with energy-dispersive X-ray analysis. Immunohistochemical studies of the tumor demonstrated glial fibrillary acid protein (GFAP) immunoreactivity in areas of glioma and focal vimentin and actin immunoreactivity in areas of sarcoma. Thorotrast-associated lesions of the central nervous system (CNS) are infrequently reported, and a Thorotrast-associated gliosarcoma has not yet been reported. The use of Thorotrast, its radiobiology, and sequelae are reviewed with particular emphasis on lesions occurring in the CNS. 52 references.

• Research Organization: George Washington Univ. Medical Center, Washington, DC (USA)
• OSTI ID: 6953480
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 62:1; ISSN CANCA
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CHEMICAL ANALYSIS
COLLOIDS
CONTRAST MEDIA
COUNTING TECHNIQUES
DISEASES
DISPERSIONS
DOCUMENT TYPES
ELECTRON MICROSCOPY
EVEN-EVEN NUCLEI
HEAVY NUCLEI
IMMUNE REACTIONS
ISOTOPES
MICROSCOPY
NEOPLASMS
NERVOUS SYSTEM
NONDESTRUCTIVE ANALYSIS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOCOLLOIDS
RADIOINDUCTION
RADIOISOTOPES
REVIEWS
SARCOMAS
SCANNING ELECTRON MICROSCOPY
SCINTILLATION COUNTING
THORIUM 232
THORIUM COMPOUNDS
THORIUM ISOTOPES
THORIUM OXIDES
THOROTRAST
TOXICITY
USES
X-RAY EMISSION ANALYSIS
YEARS LIVING RADIOISOTOPES