Thorotrast-associated sarcoma of bone: a case report and review of the literature
An osteosarcoma developed near the right lesser trochanter of a 55-year-old woman. The neoplasm fulfilled the generally accepted criteria for a Thorotrast related malignancy. Strenghening this relationship was the occurrence of the tumor in an unusual location and uncommon age group. Thorium waas confirmed both in the tumor and in bone marrow histiocytes by its characteristic x-ray spectrum. Including this case only twelve Thorotrast-associated neoplasms of bone have been reported. The mean latency period after Thorotrast administration was 26 years. Regression analysis revealed that latency period and Thorotrast dose are inversely related. All tumors were reported to be sarcomas. Six osteosarcomas, one fibrosarcoma, one chondrosarcoma, and one undifferentialted sarcoma were proven histologically. All patients, for whom follow-up was given, had died of the tumor. The reasons behind the low frequency of reported Thorotrast-associated bone malignancies may be the low concentration of /sup 232/Th and radioactive daughters in bone, long latency period or the general lack of knowledge concerning the possible relationship between Thorotrast and bone tumors. Statistical association between Thorotrast injection and bone sarcoma is shown. The criteria for the diagnosis of Thorotrastosis are discussed as well as the long term deleterious effects. The distribution of Thorotrast within the body is discussed as well as the associated radiographic changes.
- Research Organization:
- Massachusetts General Hospital, Boston
- OSTI ID:
- 5528811
- Journal Information:
- Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 44:6; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CHALCOGENIDES
COLLOIDS
CONNECTIVE TISSUE
CONTRAST MEDIA
DELAYED RADIATION EFFECTS
DISEASES
DISPERSIONS
DISTRIBUTION
DOCUMENT TYPES
EVEN-EVEN NUCLEI
FEMALES
FIBROSARCOMAS
HEAVY NUCLEI
ISOTOPES
MAMMALS
MAN
NEOPLASMS
NUCLEI
OSTEOSARCOMAS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
PRIMATES
RADIATION EFFECTS
RADIOCOLLOIDS
RADIOINDUCTION
RADIOISOTOPES
REVIEWS
SARCOMAS
SKELETAL DISEASES
THORIUM 232
THORIUM COMPOUNDS
THORIUM ISOTOPES
THORIUM OXIDES
THOROTRAST
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES
WOMEN
YEARS LIVING RADIOISOTOPES