Thorotrast-induced extraskeletal osteosarcoma of the cervical region: report of a case

Journal Article · Fri Oct 31 23:00:00 EST 1975 · Cancer, v. 36, no. 5, pp. 1827-1833

OSTI ID:4132982

Hasson, J; Hartman, K S; Milikow, E; Mittelman, J A

This is the seventh reported case of a soft tissue sarcoma attributed to Thorotrast extravasated during the course of an injection for arteriography. An extraskeletal osteosarcoma occurring in the cervical region of a 51-year-old man 30 years after a cerebral arteriogram is presented. The other reported cases include a fibrosarcoma, two neurofibrosarcomas, two spindle cell sarcomas, and an extraskeletal chondrosarcoma. The latency period has varied from 5 to 30 years. The Thorotrast granules are readily identified in macrophages near or adjacent to the tumor, and the demonstration of alpha tracks on autoradiographs is diagnostic. (auth)

• Research Organization: Mount Sinai Hospital, Hartford
• NSA Number: NSA-33-009609
• OSTI ID: 4132982
• Journal Information: Cancer, v. 36, no. 5, pp. 1827-1833, Journal Name: Cancer, v. 36, no. 5, pp. 1827-1833; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

*OSTEOSARCOMAS-- RADIOINDUCTION
*THOROTRAST-- CARCINOGENESIS
560161* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Man
AUTORADIOGRAPHY
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
N48610* --Life Sciences--Radionuclide Effects (Internal Source)--Man
PATIENTS
TISSUES