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Synthesis of radiopharmaceuticals containing short-lived radionuclides: Comprehensive progress report, March 1, 1986-February 28, 1989

Technical Report ·
OSTI ID:6950030
The primary objective of the DOE Nuclear Medicine Program at The University of Tennessee is the creation of new methods for intoducing short-lived isotopes into agents for use in PET and SPECT. A portion of our effort is directed toward the design and in vivo quantitation of boron-containing neutron therapy agents. The uniqueness of the program is its focus on the design of new chemistry (molecular architecture) and technology as opposed to the application of known reactions to the synthesis of specific radiopharmaceuticals. The following topics are outlined in this paper: new isotope incorporation reactions utilizing nitrogen 13, oxygen 15, and carbon 11; technetium-boron complexes; boron-neutron-capture.
Research Organization:
Tennessee Univ., Knoxville (USA). Dept. of Chemistry
DOE Contract Number:
FG05-86ER60434
OSTI ID:
6950030
Report Number(s):
DOE/ER/60434-3; ON: DE88011524
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400700* -- Radiochemistry & Nuclear Chemistry
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORON
BORON 11
BORON ISOTOPES
CARBON 11
CARBON ISOTOPES
CHEMICAL REACTION KINETICS
CHEMICAL REACTIONS
COMPLEXES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HALOGENATION
IMAGES
IODINATION
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NITROGEN 13
NITROGEN ISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OXYGEN 15
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOISOTOPES
RADIOPHARMACEUTICALS
REACTION KINETICS
RESEARCH PROGRAMS
SEMIMETALS
STABLE ISOTOPES
SYNTHESIS
TECHNETIUM COMPLEXES
TOMOGRAPHY
TRANSITION ELEMENT COMPLEXES