Boron in nuclear medicine: New synthetic approaches to PET, SPECT and BNCT agents

Technical Report · Mon Oct 01 04:00:00 EDT 1990

DOI:https://doi.org/10.2172/6648872· OSTI ID:6648872

Kabalka, G W

The primary objective of the Department of Energy (DOE) Nuclear Medicine Program at the University of Tennessee is the creation of new methods for introducing short-lived isotopes into agents for use in PET and SPECT. A small, but significant portion of our effort is directed toward the design of boron-containing neutron therapy agents. The uniqueness of the UT program is its focus on the design of new chemistry (molecular architecture) and technology as opposed to the application of know reactions to the synthesis of specific radiopharmaceuticals. The new technology is then utilized in nuclear medicine research at the UT Biomedical Imaging Center and in collaboration with colleagues at other DOE facilities (Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory, and Oak Ridge Associated Universities). An important goal of the DOE Nuclear Medicine Program at UT is to provide training for students (predoctoral and postdoctoral) in the scientific aspects of nuclear medicine. The academic nature of the program facilitates collaborative interactions with other DOE nuclear medicine programs and helps to insure the continued availability of skilled scientists dedicated to the advancement of nuclear medicine.

• Research Organization: Tennessee Univ., Knoxville, TN (USA). Dept. of Chemistry
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG05-86ER60434
• OSTI ID: 6648872
• Report Number(s): DOE/ER/60434-5; ON: DE90017335
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORON 11
BORON ISOTOPES
CARBON 11
CARBON ISOTOPES
CHEMICAL REACTIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HALOGENATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINATION
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NITROGEN 13
NITROGEN ISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RESEARCH PROGRAMS
STABLE ISOTOPES
SYNTHESIS
THERAPY
TOMOGRAPHY
TRAINING