Boron in nuclear medicine: New synthetic approaches to PET, SPECT, and BNCT agents

Technical Report · Sun Sep 01 04:00:00 EDT 1991

OSTI ID:5507371

Kabalka, G W

The primary objective of the DOE Nuclear Medicine Program at The University of Tennessee is the creation of new methods for introducing short-lived isotopes into agents for use in computerized tomography. A portion of the research effort is directed toward the development of new synthetic methods for the preparation of boron-containing neutron therapy agents. The uniqueness of the UT program is its focus on the design of new chemistry and technology as opposed to the application of known reactions to the synthesis of specific radiopharmaceuticals. The versatile organic boron reagents are utilized in most of the new chemistry. This new technology is then used in nuclear medicine research at the UT Biomedical Imaging Center and in collaborative research programs with colleagues at other DOE facilities. An important goal of the DOE Nuclear Medicine Program at UT is to provide training for students (predoctoral and postdoctoral) in the scientific aspects of nuclear medicine. 83 refs., 12 figs.

• Research Organization: Tennessee Univ., Knoxville, TN (United States). Dept. of Chemistry
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-86ER60434
• OSTI ID: 5507371
• Report Number(s): DOE/ER/60434-6; ON: DE91016488
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORON 11
BORON COMPOUNDS
BORON ISOTOPES
CARBON 11
CARBON ISOTOPES
CHEMICAL PREPARATION
CHEMICAL REACTIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HALOGENATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINATION
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NANOSEC LIVING RADIOISOTOPES
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NITROGEN 13
NITROGEN ISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC BORON COMPOUNDS
ORGANIC COMPOUNDS
OXYGEN 15
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RESEARCH PROGRAMS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STABLE ISOTOPES
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TOMOGRAPHY
TRAINING
YEARS LIVING RADIOI