Metabolism of 25-hydroxyvitamin D in copper-laden rat: A model of Wilson's disease

Journal Article · Mon Feb 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6948881

Carpenter, T O; Pendrak, M L; Anast, C S ^[1]

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1. Harvard Medical School, Boston (USA) Yale Univ. School of Medicine, New Haven, CT (USA)

Wilson's disease results in excess tissue accumulation of copper and is often complicated by skeletal and mineral abnormalities. The authors investigated vitamin D metabolism in rats fed a copper-laden diet rendering hepatic copper content comparable with that found in Wilson's disease. Injection of 25-hydroxyvitamin D{sub 3} (25(OH)D{sub 3}) resulted in reduced 1,25--dihydroxyvitamin D (1,25(OH){sub 2}D) levels in copper-intoxicated rats. In vitro 25(OH)D-1{alpha}-hydroxylase activity was impaired in renal mitochondria from copper-intoxicated animals. Activity was also inhibited in mitochondrial from controls when copper was added to incubation media. Impaired conversion of 25(OH)D to 1,25(OH){sub 2}D occurs in copper intoxication and suggests that altered vitamin D metabolism is a potential factor in the development of bone and mineral abnormalities in Wilson's disease.

• OSTI ID: 6948881
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:2; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHOLECALCIFEROL
CHROMATOGRAPHY
COPPER COMPOUNDS
DISEASES
ENZYME ACTIVITY
ENZYMES
HORMONES
HYDROGEN COMPOUNDS
HYDROXYLASES
KIDNEYS
MAMMALS
METABOLISM
MITOCHONDRIA
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PARATHORMONE
PATHOGENESIS
PEPTIDE HORMONES
RADIOCHROMATOGRAPHY
RATS
RODENTS
SEPARATION PROCESSES
SKELETAL DISEASES
TRANSITION ELEMENT COMPOUNDS
TRITIUM COMPOUNDS
VERTEBRATES
VITAMIN D
VITAMINS