Presynaptic control of dopamine release by BETA-phenylethylamine
The authors study the effect of extracellular ions (Ca/sup 2 +/, Na/sup 2 +/) on the beta-phenylethylamine (beta-PEA) releasing effect, dependence of this effect on the membrane potential of dopaminergic endings, and the participation of dopamine presynaptic autoreceptors in the realization of the effects of beta-PEA on dopamine (DA) release. Experi ments were carried out on noninbred male albino rats. By means of a microsyringe, (/sup 3/H)-DA hydrochloride was injected. The significance of the difference in levels of (/sup 3/H)-DA release during analogous periods of perfusion in the groups of animals compared was estimated by Student's test. These experiments in vivo thus demonstrated the ability of beta-PEA to regulate DA release in different directions depending on the functional state of the dopaminergic neuron.
- Research Organization:
- Institute of Biological Physics, Acad. of Sci., Pushchino
- OSTI ID:
- 6942569
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 98:11
- Country of Publication:
- United States
- Language:
- English
Similar Records
Membrane events and ionic processes involved in dopamine release from tuberoinfundibular neurons. II. Effect of the inhibition of the Na+-Ca++ exchange by amiloride
Membrane events and ionic processes involved in dopamine release from tuberoinfundibular neurons. I. Effect of the inhibition of the Na+,K+-adenosine triphosphatase pump by ouabain
Related Subjects
CALCIUM COMPOUNDS
BIOLOGICAL EFFECTS
DOPAMINE
BIOELECTRICITY
RECEPTORS
UPTAKE
NERVE CELLS
RADIORECEPTOR ASSAY
SODIUM COMPOUNDS
AMINES
BIOCHEMISTRY
CELL MEMBRANES
PERFUSED ORGANS
RATS
TRITIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CHEMISTRY
DRUGS
ELECTRICITY
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
RODENTS
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES
550301* - Cytology- Tracer Techniques
550501 - Metabolism- Tracer Techniques