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Presynaptic control of dopamine release by BETA-phenylethylamine

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6942569
;

The authors study the effect of extracellular ions (Ca/sup 2 +/, Na/sup 2 +/) on the beta-phenylethylamine (beta-PEA) releasing effect, dependence of this effect on the membrane potential of dopaminergic endings, and the participation of dopamine presynaptic autoreceptors in the realization of the effects of beta-PEA on dopamine (DA) release. Experi ments were carried out on noninbred male albino rats. By means of a microsyringe, (/sup 3/H)-DA hydrochloride was injected. The significance of the difference in levels of (/sup 3/H)-DA release during analogous periods of perfusion in the groups of animals compared was estimated by Student's test. These experiments in vivo thus demonstrated the ability of beta-PEA to regulate DA release in different directions depending on the functional state of the dopaminergic neuron.

Research Organization:
Institute of Biological Physics, Acad. of Sci., Pushchino
OSTI ID:
6942569
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 98:11; ISSN BEXBA
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BIOELECTRICITY
BIOLOGICAL EFFECTS
BODY
CALCIUM COMPOUNDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CELL MEMBRANES
CHEMISTRY
DOPAMINE
DRUGS
ELECTRICITY
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NERVE CELLS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PERFUSED ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RODENTS
SODIUM COMPOUNDS
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES