Tracer studies with aortic infusion result in improper tracer distribution

Conference · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:6942271

Wisneski, J A; Brooks, G A; Neese, R A; Stanley, W C; Morris, D L; Gertz, E W

It has been suggested that lactate turnover can be accurately assessed by infusing radioactive lactate tracer into the aorta and sampling blood in the vena cava. However, there may be streaming of newly infused tracer in the aorta, resulting in a nonuniform arterial specific activity (SA). Furthermore vena caval blood may not be representative of mixed venous blood. The authors examined this problem in 7 anesthetized dogs with sampling catheters in the pulmonary (PA), carotid (CA), and femoral (FA) arteries, and the superior (SVC) and inferior (IVC) vena cavi. (1-/sup 14/C)lactate was continuously infused into the left ventricle through a catheter introduced through the femoral artery. The same SA (dpm/..mu..mol) was found in the CA and FA, indicating adequate mixing of newly infused tracer with trace. Three dogs showed differences between SVC, IVC and PA, suggesting a mixed venous sample can not be obtained from the VC. When the catheter was moved into the aorta, wide differences in SA appeared between the CA and FA, clearly reflecting streaming of tracer. These differences also appeared in the SVC and IVC. In conclusion, adequate mixing does not occur between tracer and trace in arterial blood with aortic infusion. Further, VC sampling will not give a consistent mixed venous SA. Therefore, for practical reasons, aortic tracer infusion with vena caval sampling will lead to erroneous turnover values.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6942271
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AORTA
ARTERIES
BLOOD FLOW
BLOOD VESSELS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
DOGS
ERRORS
HEART
INFUSION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTATES
MAMMALS
METABOLISM
ORGANS
TRACER TECHNIQUES
VERTEBRATES