Aspects of the regulation of long-chain fatty acid oxidation in bovine liver
Journal Article
·
· J. Dairy Sci.; (United States)
Factors involved in regulation of bovine hepatic fatty acid oxidation were examined using liver slices. Fatty acid oxidation was measured as the conversion of l-(/sup 14/C) palmitate to /sup 14/CO/sub 2/ and total (/sup 14/C) acid-soluble metabolites. Extended (5 to 7 d) fasting of Holstein cows had relatively little effect on palmitate oxidation to acid-soluble metabolites by liver slices, although oxidation to CO/sup 2/ was decreased. Feeding a restricted roughage, high concentrate ration to lactating cows resulted in inhibition of palmitate oxidation. Insulin, glucose, and acetate inhibited palmitate oxidation by bovine liver slices. The authors suggest the regulation of bovine hepatic fatty acid oxidation may be less dependent on hormonally induced alterations in enzyme activity as observed in rat liver and more dependent upon action of rumen fermentation products or their metabolites on enzyme systems involved in fatty acid oxidation.
- Research Organization:
- Michigan State Univ., East Lansing
- OSTI ID:
- 6942167
- Journal Information:
- J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 69:9; ISSN JDSCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CATTLE
CHALCOGENIDES
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
GLANDS
GLUCOSE
HEXADECANOIC ACID
HEXOSES
HORMONES
INSULIN
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
METABOLISM
METABOLITES
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PEPTIDE HORMONES
RESPONSE MODIFYING FACTORS
RUMINANTS
SACCHARIDES
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CATTLE
CHALCOGENIDES
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
GLANDS
GLUCOSE
HEXADECANOIC ACID
HEXOSES
HORMONES
INSULIN
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
METABOLISM
METABOLITES
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PEPTIDE HORMONES
RESPONSE MODIFYING FACTORS
RUMINANTS
SACCHARIDES
TRACER TECHNIQUES
VERTEBRATES