Cerebral blood flow imaging with thallium-201 diethyldithiocarbamate SPECT

Journal Article · Sun Feb 01 04:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:6941710

van Royen, E A; de Brune, J F.H.; Hill, T C; Vyth, A; Limburg, M; Byse, B L; O'Leary, D H; de Jong, J M; Hijdra, A; van der Schoot, J B

Thallium-201 diethyldithiocarbamate ((/sup 201/TI)DDC) was studied in humans as an agent for cerebral blood flow imaging. Brain uptake proved to be complete 90 sec after injection with no appreciable washout or redistribution for hours. Intracarotid injection suggested an almost 100% extraction during the first passage. Whole-body distribution studies demonstrated a brain uptake of 4.3% of the dose compared with 0.9% for (/sup 201/TI)chloride. No differences were found in the distribution of (/sup 201/TI)DDC versus (/sup 201/TI)chloride in other organs. After the injection of 3 mCi /sup 201/TI, good quality single photon emission computed tomographic (SPECT) images of the brain were obtained with both a rotating gamma camera and a multidetector system. In ischemic brain disease, perfusion defects were easily demonstrated. We conclude that (/sup 201/TI)DDC is a suitable radiopharmaceutical for SPECT studies of cerebral blood flow.

• Research Organization: Univ. of Amsterdam, The Netherlands
• OSTI ID: 6941710
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
HEAVY NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
UPTAKE
VASCULAR DISEASES