Autoradiographic comparison of thallium-201 diethyldithiocarbamate, isopropyliodoamphetamine and iodoantipyrine as cerebral blood flow tracers

Journal Article · Wed Apr 01 04:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:6408199

Lear, J L; Navarro, D

We investigated (/sup 201/Tl)diethyldithiocarbamate (DDC) as a tracer for local cerebral blood flow (LCBF). Awake male rats were given intravenous infusions of a mixture of DDC and reference tracer(s): (/sup 123/I)isopropyliodoamphetamine (IMP) and/or (/sup 14/C)iodoantipyrine (IAP). LCBF values for DDC, IMP, and IAP were measured using simultaneous multiple radionuclide autoradiography and quantitative digital image analysis. Patterns of local cerebral blood flow (LCBF) obtained with DDC were intermediate compared to IMP and IAP, although they were more similar to those of IMP. DDC and IMP underestimated LCBF in some white matter and adjacent structures, while IAP underestimated LCBF values in high flow regions. We conclude that DDC uptake generally reflects local cerebral blood flow and that it can therefore be used as a cerebral perfusion tracer in humans using SPECT imaging.

• Research Organization: Univ. of Colorado Health Sciences Center, Denver
• OSTI ID: 6408199
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
ANIMALS
ANTIPYRETICS
ANTIPYRINE
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
AZOLES
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBAMATES
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRAZOLES
PYRAZOLINES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYMPATHOMIMETICS
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
VERTEBRATES