Thallium-201 diethyldithiocarbamate: an alternative to iodine-123 N-isopropyl-p-iodoamphetamine

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5400716

de Bruine, J F; van Royen, E A; Vyth, A; de Jong, J M.B.V.; van der Schoot, J B

The study of cerebral blood flow by single photon emission computed tomography (SPECT) requires lipophilic radiopharmaceuticals. The high cost and limited availability of N-isopropyl-p-(I-123)-iodoamphetamine ((/sup 123/I)IMP) led the authors to search for alternatives. Following the recent development of thallium-201 diethyldithiocarbamate ((/sup 201/Tl)DDC), the authors have compared the brain uptake of (/sup 123/I)IMP and (/sup 201/Tl)DDC in rabbits. The (/sup 201/Tl)DDC uptake was more instantaneous than that of (/sup 123/I)IMP. The ratios of gray to white matter distribution were about equal. In brain macroautoradiography (/sup 201/Tl)DDC yielded images of good quality with excellent demarcation of gray and white matter, persisting for at least 45 min after injection. They conclude that (/sup 123/I)IMP and (/sup 201/Tl)DDC are equally suitable for blood flow study of the rabbit brain. The first human tomographic results obtained in two healthy volunteers demonstrate that clinical application of SPECT (/sup 201/Tl)DDC may be feasible.

• Research Organization: Academic Medical Center, Amsterdam, Netherlands
• OSTI ID: 5400716
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHELATING AGENTS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DEDTC
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
RABBITS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
THALLIUM 201
THALLIUM ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
UPTAKE
VERTEBRATES