Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Am. J. Psychiatry; (United States)

OSTI ID:6941598

Volkow, N D; Wolf, A P; Van Gelder, P; Brodie, J D; Overall, J E; Cancro, R; Gomez-Mont, F

Using (11C)-deoxy-D-glucose and positron emission tomography (PET), the authors measured brain metabolism in 18 patients with chronic schizophrenia to assess which of the metabolic measures from two test conditions was more closely related to the patients' differing clinical characteristics. The two conditions were resting and activation, and an eye tracking task was used. Patients with more negative symptoms showed lower global metabolic rates and more severe hypofrontality than did the patients with fewer negative symptoms. Differences among the patients were distinguished by the task: sicker patients failed to show a metabolic activation response. These findings suggest that cerebral metabolic patterns reflect clinical characteristics of schizophrenic patients.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 6941598
• Journal Information: Am. J. Psychiatry; (United States), Journal Name: Am. J. Psychiatry; (United States) Vol. 2; ISSN AJPSA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
ISOTOPES
LIGHT NUCLEI
MENTAL DISORDERS
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
USES