Patterns of metabolic activity in the treatment of schizophrenia
Journal Article
·
· Ann. Neurol.; (United States)
Six patients with chronic schizophrenia were studied with positron emission tomography (PET) before and after neuroleptic treatment, using fluorine-18-labeled fluorodeoxyglucose. After treatment, the mean whole-slice glucose metabolic rate at the level of the basal ganglia showed a 25% increase. However, patterns of frontal hypometabolism observed with the schizophrenic patients were not altered by medication. Pattern analysis using the fast Fourier transform was applied to a set of 422 images from a mixed group of normal, depressed, and schizophrenic subjects. Reconstruction of the images with low-frequency coefficients was excellent, reducing considerably the number of variables needed to characterize each image. Hierarchical cluster analysis categorized the transformed images according to anatomical level and subject group (patient versus control). The results suggest the utility of this procedure for the classification and characterization of metabolic PET images from psychiatric patients. 8 references, 3 figures, 1 table.
- Research Organization:
- New York Univ. Medical Center, NY
- OSTI ID:
- 6388733
- Journal Information:
- Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 15:4; ISSN ANNED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DATA
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EXPERIMENTAL DATA
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
INFORMATION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METABOLIC DISEASES
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DATA
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EXPERIMENTAL DATA
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
INFORMATION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METABOLIC DISEASES
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY