Regional brain glucose metabolism in chronic schizophrenia. A positron emission transaxial tomographic study

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Arch. Gen. Psychiatr.; (United States)

DOI:https://doi.org/10.1001/archpsyc.1984.01790140083010· OSTI ID:6849767

Farkas, T; Wolf, A P; Jaeger, J; Brodie, J D; Christman, D R; Fowler, J S

Thirteen diagnosed schizophrenics and 11 normal controls were studied with a method using the PETT III positron emission tomograph (PET) and fluorodeoxyglucose labeled with fluorine 18. Each subject also had a computed tomographic (CT) scan. For each subject, two brain levels, one through the basal ganglia and one through the semioval center, were analyzed for the mean regional metabolic glucose rate. Specifically, relationships between frontal and posterior regions were evaluated. The CT scans of matching levels were superimposed on the functional PET images to provide anatomic criteria for region of interest selection. While no whole-slice metabolic differences were apparent between groups, schizophrenics had significantly lower activity in the frontal lobes, relative to posterior regions. The medicated and drug-free groups did not differ from one another in these regards. Trait v state dependency of the phenomenon was analyzed, and several technological limitations were considered.

• Research Organization: New York University Medical Center, NY
• OSTI ID: 6849767
• Journal Information: Arch. Gen. Psychiatr.; (United States), Journal Name: Arch. Gen. Psychiatr.; (United States) Vol. 41:3; ISSN ARGPA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
GLUCOSE
HEXOSES
MENTAL DISORDERS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
SACCHARIDES
TOMOGRAPHY