Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography

Journal Article · Wed May 01 04:00:00 EDT 1985 · Am. J. Psychiatry; (United States)

OSTI ID:5553459

Wolkin, A; Jaeger, J; Brodie, J D; Wolf, A P; Fowler, J; Rotrosen, J; Gomez-Mont, F; Cancro, R

Local cerebral metabolic rates were determined by positron emission tomography and the deoxyglucose method in a group of 10 chronic schizophrenic subjects before and after somatic treatment and in eight normal subjects. Before treatment, schizophrenic subjects had markedly lower absolute metabolic activity than did normal controls in both frontal and temporal regions and a trend toward relative hyperactivity in the basal ganglia area. After treatment, their metabolic rates approached those seen in normal subjects in nearly all regions except frontal. Persistence of diminished frontal metabolism was manifested as significant relative hypofrontality. These findings suggest specific loci of aberrant cerebral functioning in chronic schizophrenia and the utility of positron emission tomography in characterizing these abnormalities.

• Research Organization: New York Univ. Medical Center, NY
• OSTI ID: 5553459
• Journal Information: Am. J. Psychiatry; (United States), Journal Name: Am. J. Psychiatry; (United States) Vol. 142:5; ISSN AJPSA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
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DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
MENTAL DISORDERS
METABOLIC DISEASES
METABOLISM
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ORGANS
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