Mirex uptake and tissue disposition in intact and adrenalectomized rats

Journal Article · Mon Mar 14 23:00:00 EST 1988 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(88)90174-3· OSTI ID:6939243

Brown, L D; Yarbrough, J D

The toxicity of mirex, an organochlorine insecticide, is increased significantly in adrenalectomized rats. To determine if this might be due to alterations in the tissue distribution of mirex, a disposition study was conducted in intact, adrenalectomized, and adrenalectomized corticosterone-supplemented rats. The peak plasma levels of (14C)mirex were shifted from 2 hr in intact and adrenalectomized corticosterone-supplemented rats to 4 hr in the adrenalectomized rats. The initial uptake and disposition of (14C)mirex in the brain of the intact, adrenalectomized, and adrenalectomized corticosterone-supplemented rats was essentially the same from 0.5 to 6 hr after dosing. By 48 hr after dosing, the (14C)mirex concentration in the brain of intact and adrenalectomized rats was significantly higher than that in adrenalectomized corticosterone-supplemented rats. Brain to plasma ratios reflected this difference. Corticosterone supplements to adrenalectomized rats decreased the absorption of (14C)mirex in the brain. The uptake of (14C)mirex during the initial 6 hr after dosing in all other tissues studied (liver, kidney, testes, and omental fat) was essentially the same for the three treatment groups. By 48 hr postdose, (14C)mirex concentration per liver was significantly higher in intact than in adrenalectomized and adrenalectomized corticosterone-supplemented rats. The difference in (14C)mirex disposition between the three treatment groups was not due to alterations in metabolism or elimination.

• OSTI ID: 6939243
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 92:3; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALECTOMY
ANIMALS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CORTICOSTEROIDS
CORTICOSTERONE
DIGESTIVE SYSTEM
DISTRIBUTION
GLANDS
GLUCOCORTICOIDS
HYDROXY COMPOUNDS
INSECTICIDES
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
LIVER
MAMMALS
MEDICINE
METABOLISM
NERVOUS SYSTEM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
PREGNANES
RATS
RODENTS
STEROIDS
SURGERY
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
UPTAKE
VERTEBRATES