Autoradiographic analysis of hepatocytes in mirex-induced adaptive liver growth

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:6896348

Wilson, D; Yarbrough, J D ^[1]

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1. Mississippi State Univ., MS (USA)

The relationships between ({sup 3}H)thymidine incorporation into hepatocyte nuclei, cell enlargement, and mitotic index were studied in intact (INT) and adrenalectomized (ADX) mirex-dosed rats. In INT mirex-dosed rats the sequence of events included the following: a biphasic response in nuclear labeling of mononuclear hepatocyes with peaks at 48 and 66 h postmirex dose, a peak in mitotic activity 66 h postmirex dose, and a significant increase in binuclear hepatocyte size 48 h postmirex dose. In ADX mirex-dosed rats the sequence of events included the following: a biphasic response in nuclear labeling mononuclear hepatocytes with peaks at 24 and 48 h postmirex dose, a peak in mitotic activity 60 h postmirex dose, and a marginal increase in binuclear hepatocyte size 48 h postmirex dose. Corticosterone supplements to ADX mirex-dosed rats significantly reduced nuclear labeling of the mononuclear hepatocytes and increased the size of binuclear hepatocytes to that observed in INT mirex-dosed rats. This study demonstrates that adaptive liver growth consists of a hyperplastic response that involves mononuclear hepatocytes and a hypertrophic response that involves binuclear hepatocytes. Both responses appear to be modulated by corticosterone.

• OSTI ID: 6896348
• Journal Information: American Journal of Physiology; (USA), Vol. 255:1; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LIVER CELLS
AUTORADIOGRAPHY
THYMIDINE
UPTAKE
XENOBIOTICS
BIOLOGICAL EFFECTS
ADRENALECTOMY
CELL CYCLE
CORTICOSTERONE
HYPERTROPHY
LIVER
MITOTIC INDEX
RATS
TRITIUM COMPOUNDS
ADRENAL HORMONES
ANIMAL CELLS
ANIMALS
AZINES
BODY
CORTICOSTEROIDS
DIGESTIVE SYSTEM
GLANDS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
KETONES
MAMMALS
MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANES
PYRIMIDINES
RIBOSIDES
RODENTS
SOMATIC CELLS
STEROIDS
SURGERY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics