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Autoradiographic analysis of hepatocytes in mirex-induced adaptive liver growth

Journal Article · · American Journal of Physiology; (USA)
OSTI ID:6896348
;  [1]
  1. Mississippi State Univ., MS (USA)
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The relationships between ({sup 3}H)thymidine incorporation into hepatocyte nuclei, cell enlargement, and mitotic index were studied in intact (INT) and adrenalectomized (ADX) mirex-dosed rats. In INT mirex-dosed rats the sequence of events included the following: a biphasic response in nuclear labeling of mononuclear hepatocyes with peaks at 48 and 66 h postmirex dose, a peak in mitotic activity 66 h postmirex dose, and a significant increase in binuclear hepatocyte size 48 h postmirex dose. In ADX mirex-dosed rats the sequence of events included the following: a biphasic response in nuclear labeling mononuclear hepatocytes with peaks at 24 and 48 h postmirex dose, a peak in mitotic activity 60 h postmirex dose, and a marginal increase in binuclear hepatocyte size 48 h postmirex dose. Corticosterone supplements to ADX mirex-dosed rats significantly reduced nuclear labeling of the mononuclear hepatocytes and increased the size of binuclear hepatocytes to that observed in INT mirex-dosed rats. This study demonstrates that adaptive liver growth consists of a hyperplastic response that involves mononuclear hepatocytes and a hypertrophic response that involves binuclear hepatocytes. Both responses appear to be modulated by corticosterone.
OSTI ID:
6896348
Journal Information:
American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:1; ISSN 0002-9513; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ADRENALECTOMY
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BODY
CELL CYCLE
CORTICOSTEROIDS
CORTICOSTERONE
DIGESTIVE SYSTEM
GLANDS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
HYPERTROPHY
KETONES
LIVER
LIVER CELLS
MAMMALS
MEDICINE
MITOTIC INDEX
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANES
PYRIMIDINES
RATS
RIBOSIDES
RODENTS
SOMATIC CELLS
STEROIDS
SURGERY
THYMIDINE
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
XENOBIOTICS