Nuclear Medicine Program progress report for quarter ending June 30, 1990

Technical Report · Wed Aug 01 04:00:00 EDT 1990

OSTI ID:6939010

Knapp, Jr, F F; Ambrose, K R; Callahan, A P; McPherson, D W; Mirzadeh, S; Srivastava, P C; Allred, J F; Hasan, A; Lambert, C R; Lambert, S J; Rice, D E

In this a report novel electrochemical method is described for the separation of copper-64 and copper-67 following the irradiation of zinc targets. This method is based on the spontaneous electrodeposition of copper on a platinum electrode immersed in the zinc target solution without requiring an external electromotive force (EMF). No-carrier-added N-(2-(3-({sup 125}I)iodo-4-hydroxyphenyl)ethyl)-maleimide has been prepared by direct iodination of N-(2-(4-hydroxyphenyl)ethyl)-maleimide with (Na({sup 125}I)-chloramine-T). The precursor was prepared by condensation of tyramine with maleic anhydride followed by ring annulation. Studies in rats showed low thyroid uptake of radioactivity which reached a plateau after 4 h, indicating in vivo stability. This new radioiodinated maleimide analogue reacts with bovine serum albumin (BSA) under mild conditions and has been used for labeling a lung-endothelial-cell-specific antibody (411-201B). The ({sup 125}I)-labeled antibodies are currently being evaluated for immunoreactivity and tumor specificity. During this period several agents were also supplied to Medical Cooperative investigators, including iodine-123-labeled and iodine-131-labeled fatty acid analogues for studies at the Brookhaven National Laboratory, the Cardiology Department at the Free University of Amsterdam, and the University of Bonn, West Germany. A tungsten-188/rhenium-188 generator was supplied to the University of Massachusetts, and osmium-191 was supplied for fabrication of generators for patient studies in Finland. 4 refs., 5 figs., 5 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6939010
• Report Number(s): ORNL/TM-11570; ON: DE90016681
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
AMINES
ANIMALS
ANTIBODIES
AQUEOUS SOLUTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHEMISTRY
CHLORAMINES
COPPER
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DEPOSITION
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
DOCUMENT TYPES
DRUGS
ELECTROCHEMISTRY
ELECTRODEPOSITION
ELECTROLYSIS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-EVEN NUCLEI
GASTROINTESTINAL TRACT
HALOGENATION
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IODINATION
IODINE 123
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LARGE INTESTINE
LUNGS
LYSIS
MAMMALS
MEDICINE
METALS
MINUTES LIVING RADIOISOTOPES
MIXTURES
MONOCARBOXYLIC ACIDS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PROGRESS REPORT
PROTEINS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RATS
RESPIRATORY SYSTEM
RHENIUM 188
RHENIUM ISOTOPES
RODENTS
SOLUTIONS
SPECIFICITY
SURFACE COATING
THERAPY
TRANSITION ELEMENTS
TUNGSTEN 188
TUNGSTEN ISOTOPES
VERTEBRATES