Nuclear Medicine Program progress report for quarter ending September 30, 1990

Technical Report · Fri Feb 01 04:00:00 EST 1991

OSTI ID:6228890

Knapp, Jr, F F; Ambrose, K R; Callahan, A P; McPherson, D W; Mirzadeh, S; Srivastava, P C; Allred, J F; Hasan, A; Lambert, C R; Lambert, S J; Rice, D E

An evaluation of the Oak Ridge National Laboratory (ORNL) alumina-based tungsten-188/rhenium-188 (W-188/Re-188) generator system has continued. Our goal is to develop a prototype system which will provide sufficient levels of Re-188 for radiolabeling of tumor-specific antibodies for radioimmunotherapy. During this review period several samples were supplied for collaborative studies. Samples of rhenium-188 from the ORNL W-188/Re-188 generators were supplied to the National Institutes of Standards and Technology (NIST) as a calibration standard. Iodine-125-labeled IMP protein labeling agent was supplied to the University of Michigan for antibody radiolabeling studies (D. Buchsbaum, Ph.D.). The iodine-123-labeled BMIPP fatty acid analogue developed at ORNL was also supplied to collaborators at BNL for SPECT imaging studies of the effects of cocaine intoxication on myocardial fatty acid uptake in a canine model. Iodine-125-BMIPP was also supplied to the University of Bonn, Germany for continuing metabolic studies in an isolated heart model. In this report the resumption of radioisotope production in the HFIR following the restart of this important facility in July 1990 and the preparation and review and evaluation of issues for the DOE Tiger Team visit to ORNL on November 1--December 7 are also discussed. 2 figs., 1 tab.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: DOE/DP
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6228890
• Report Number(s): ORNL/TM-11721; ON: DE91007663
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALOIDS
ANESTHETICS
ANIMALS
ANTIBODIES
ANTIDEPRESSANTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL REACTIONS
COCAINE
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENRICHED URANIUM REACTORS
EVEN-EVEN NUCLEI
HALOGENATION
HEAVY NUCLEI
HFIR REACTOR
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINATION
IODINE 123
IODINE 135
IODINE ISOTOPES
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEDICINE
METABOLISM
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROGRESS REPORT
PSYCHOTROPIC DRUGS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RHENIUM 188
RHENIUM ISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYNTHESIS
TANK TYPE REACTORS
TEST REACTORS
THERAPY
THERMAL REACTORS
TOMOGRAPHY
TUNGSTEN 188
TUNGSTEN ISOTOPES
UPTAKE
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS