Hormonal status and fluid electrolyte metabolism in motion sickness
In the first experimental series, 10 healthy male test subjects with a high susceptibility to motion sickness showed a significant increase of ACTH, cortisol, STH, prolactin, ADH, aldosterone concentrations, and plasma renin activity after vestibular tests. The 10 subjects with a moderate susceptibility exhibited a still higher increase of the hormones, except plasma renin. The 8 test subjects with a low susceptibility displayed a considerable increase in ACTH, cortisol, and STH after vestibular stimulation. In the second experimental series, the increase of STH, cortisol, ADH, aldosterone and renin occurred immediately after rotation in the moderate susceptibility subjects and an hour after exposure in the high susceptibility subjects. This may be indicative of specific immediate adaptation mechanisms or excitation transfer in the CNS in high susceptibility persons. In the third experimental animal series, the permeability of the blood-brain barrier for /sup 125/I and IgG increased after rotation. Greater concentrations of potassium, chloride, and urea in CSF are suggestive of an inhibition process activation in the CNS and, probably, of an active urea transport by the vascular plexus epithelium which maintains constant osmotic pressure of cerebral extracellular fluid and prevents hyper-hydration of CNS neurons.
- Research Organization:
- Institute of Biomedical Problems, Moscow (USSR)
- OSTI ID:
- 6937455
- Journal Information:
- Aviat., Space Environ. Med.; (United States), Vol. 59:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD-BRAIN BARRIER
PERMEABILITY
ELECTROLYTES
METABOLISM
HORMONES
BIOSYNTHESIS
AUDITORY ORGANS
CORIOLIS FORCE
IODINE 125
MEMBRANE TRANSPORT
NERVOUS SYSTEM DISEASES
RABBITS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SENSE ORGANS
SYNTHESIS
VERTEBRATES
550901* - Pathology- Tracer Techniques