Zero gravity and cardiovascular homeostasis. The relationship between endogenous hyperprolactinemia and plasma aldosterone. Summary report, 1 February 1977--31 January 1978
Technical Report
·
OSTI ID:6541179
Prolactin, thyrotropin, and aldosterone were measured by radioimmunoassay and plasma renin activity by the radioimmunoassay of angiotensin I in normal women before and after the intravenous injection of 200 ..mu..g of thyrotropin-releasing-hormone. Prolactin increased at 15 min following injection of thyrotropin-releasing-hormone. Plasma renin activity was not different from control levels during the first hour following the administration of thyrotropin-releasing-hormone, nor did the plasma aldosterone concentration differ significantly from the control levels during this period. However, with upright posture, an increase in aldosterone and in plasma renin activity was noted, demonstrating a normal capacity to secrete aldosterone. Similarly, no change in aldosterone was seen in 9 patients with primary hypothyroidism given thyrotropin-releasing hormone, despite the fact that the increase in prolactin was greater than normal. These data demonstrate that acutely or chronically elevated serum prolactin levels do not result in increased plasma aldosterone levels in humans.
- Research Organization:
- Massachusetts General Hospital, Boston (USA)
- OSTI ID:
- 6541179
- Report Number(s):
- N-78-22705; NASA-CR-151715
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CORTICOSTEROIDS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
ENZYMES
FEMALES
GLANDS
GONADOTROPINS
HOMEOSTASIS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
HYPOTHYROIDISM
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KETONES
LTH
MAMMALS
MAN
MINERALOCORTICOIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PEPTIDE HYDROLASES
PITUITARY HORMONES
PREGNANES
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
RENIN
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
TRH
TSH
VERTEBRATES
WOMEN
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALDEHYDES
ALDOSTERONE
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CORTICOSTEROIDS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
ENZYMES
FEMALES
GLANDS
GONADOTROPINS
HOMEOSTASIS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
HYPOTHYROIDISM
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KETONES
LTH
MAMMALS
MAN
MINERALOCORTICOIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PEPTIDE HYDROLASES
PITUITARY HORMONES
PREGNANES
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
RENIN
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
TRH
TSH
VERTEBRATES
WOMEN