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Adrenocortical function after acute carbon monoxide exposure in humans

Journal Article · · Arch. Environ. Health; (United States)
; ;
The effect of acute carbon monoxide (CO) exposure on plasma adrenocorticotrophic hormone (ACTH), renin activity (PRA), aldosterone, and cortisol levels was studied in patients approximately 80-90 min after removal from the scene of exposure. Nine patients had carboxyhemoglobin (COHb) levels below 15%. Seven patients had COHb levels that exceeded 15% (Group II). Plasma ACTH, cortisol, and aldosterone levels were significantly higher in Group II (elevated COHb). Plasma cortisol and aldosterone levels were appropriate for the levels of ACTH and PRA achieved. It was concluded that (a) acute carbon monoxide poisoning leads to elevated plasma corticosteroid levels, and (b) the adrenal gland appears to function normally acutely after exposure to carbon monoxide.
Research Organization:
St. Luke's Hospital, Milwaukee, WI
OSTI ID:
5433620
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 40:2; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTH
ADRENAL GLANDS
ADRENAL HORMONES
AEROSOLS
ALDEHYDES
ALDOSTERONE
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARBOXYHEMOGLOBIN
CHALCOGENIDES
CHEMICAL ANALYSIS
COLLOIDS
CORTICOSTEROIDS
DATA
DATA COMPILATION
DISPERSIONS
ENDOCRINE GLANDS
ENZYMES
FUNCTIONS
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROCORTISONE
HYDROLASES
HYDROXY COMPOUNDS
INFORMATION
INHALATION
INTAKE
KETONES
MATERIALS
MEASURING METHODS
MINERALOCORTICOIDS
NONSPECIFIC PEPTIDASES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
PEPTIDE HORMONES
PEPTIDE HYDROLASES
PITUITARY HORMONES
PREGNANES
RENIN
SAMPLING
SOLS
STEROID HORMONES
STEROIDS
TOXICITY