Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Positive iodine-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal images can precede return of adrenocortical function after o,p' DDD treatment

Journal Article · · Clin. Nucl. Med.; (United States)
;

A patient with bilateral adrenal hyperplasia, due to the ectopic adrenocorticotrophic hormone (ACTH) syndrome, received a 3-month course of treatment with 1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p' DDD), which caused adrenal hypofunction requiring steroid therapy. Eleven months later, Cushing's syndrome recurred. His CT scan showed a left adrenal gland that was enlarged and a normal-sized right adrenal gland. However, the NP-59 image showed increased uptake by both glands. Venous effluent was sampled from each adrenal vein. The plasma cortisol level from the left gland was 1392 ng/ml, and that from the right gland was 667 ng/ml. The latter value was not significantly different from the values obtained at peripheral sites (517-744 ng/ml). In the course of recovery from o,p' DDD damage, the ability of the adrenal gland to take up NP-59 may be restored before the return of its biosynthetic and secretory functions. Serial NP-59 adrenal images can anticipate the recurrence of Cushing's syndrome after adrenolytic therapy, thereby permitting early retreatment.

Research Organization:
Veterans Administration Hospital, Hines, IL (USA)
OSTI ID:
7001423
Journal Information:
Clin. Nucl. Med.; (United States), Journal Name: Clin. Nucl. Med.; (United States) Vol. 13:5; ISSN CNMED
Country of Publication:
United States
Language:
English

Similar Records

Relationship of serum lipids to adrenal-gland uptake of 6. beta. -(/sup 131/I) iodomethyl-19-norcholesterol in Cushing's syndrome
Conference · Fri Oct 31 23:00:00 EST 1980 · J. Nucl. Med.; (United States) · OSTI ID:6795088
Clinical application of SPECT in adrenal imaging with iodine-131 6 beta-iodomethyl-19-norcholesterol
Journal Article · Fri Mar 31 23:00:00 EST 1989 · Clin. Nucl. Med.; (United States) · OSTI ID:6078595
Diagnostic accuracy and pitfalls of (iodine-131)6-beta-iodomethyl-19-norcholesterol (NP-59) imaging
Journal Article · Sat Mar 31 23:00:00 EST 1990 · Journal of Nuclear Medicine; (USA) · OSTI ID:6896197

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHOLESTEROL
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
DYNAMIC FUNCTION STUDIES
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROCESSING
RADIOISOTOPES
RADIOPHARMACEUTICALS
STEROIDS
STEROLS
TOMOGRAPHY
UPTAKE