Relationship of serum lipids to adrenal-gland uptake of 6. beta. -(/sup 131/I) iodomethyl-19-norcholesterol in Cushing's syndrome

Conference · Sat Nov 01 04:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:6795088

Valk, T W; Gross, M D; Freitas, J E; Swanson, D P; Schteingart, D E; Beierwaltes, W H

An alteration in serum cholesterol levels has been suggested as a possible modifier of adrenal uptake of the cholesterol analog, 6..beta..-(/sup 131/I)iodomethyl-19-norcholesterol (NP-59). To assess the effect of hypercholesterolemia upon NP-59 adrenal uptake, patients with Cushing's syndrome (eight with pituitary-dependent, four with ACTH-independent, and two with ectopic-ACTH syndrome) were selected for retrospective analysis based on the availability of serum cholesterol (n = 14) and triglyceride (n = 10) concentrations obtained at the time of adrenal scintigraphy. A negative correlation (r = -0.78, p < 0.01) was found between NP-59 uptake and serum cholesterol levels in patients with pituitary-dependent Cushing's disease. Compared with pituitary-dependent disease, the ectopic-ACTH syndrome and ACTH-independent states demonstrated equal or greater adrenal uptake of NP-59 at similar serum cholesterol concentrations. Serum triglyceride concentrations did not correlate with total adrenal uptake of NP-59 in any of the patient groups studied. Increased serum cholesterol concentrations are associated with diminished adrenal uptake of NP-59, and in some cases may limit the diagnoic efficacy of adrenal scintigraphy in Cushing's syndrome.

• Research Organization: Univ. of Michigan, Ann Arbor
• DOE Contract Number: EY-76-S-02-2031
• OSTI ID: 6795088
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 21:11
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHOLESTEROL
COUNTING TECHNIQUES
CUSHING SYNDROME
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
IMMUNE SERUMS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LIPIDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
QUANTITY RATIO
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPONSE MODIFYING FACTORS
SCINTISCANNING
STEROIDS
STEROLS
UPTAKE
USES