Adrenal scanning and uptake with /sup 131/1-6. beta. -iodomethyl-nor-cholesterol
Adrenal scans were obtained in 50 patients with suspected adrenal disease; /sup 131/I-19-iodocholesterol was used in 12 and /sup 131/I-6-..beta..-iodomethyl cholesterol (NP-59) in 38 cases (42 scans). The scan diagnosis was correct in 48 patients. Successful images were obtained with 0.5 mCi, or less, of NP-59 instead of the standard dose of 2 mCi, thus reducing radiation dose to the patient and cost of the agent. Satisfactory scans were obtained in 2 to 3 days in patients with hyperfunctioning adrenals, and in 3 to 7 days in other groups of patients, when NP-59 was used. With /sup 131/I-19-iodocholesterol, however, 5 to 10 days were required for optimal results in all patients including those with Cushing disease. Adrenal uptake studies were very useful in the evaluation of adrenal function, particularly in differentiating bilateral hyperplasia from normal adrenals.
- Research Organization:
- Michael Reese Hospital and Medical Center, Chicago
- OSTI ID:
- 6740786
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 128:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHOLESTEROL
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
DRUGS
DYNAMIC FUNCTION STUDIES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
STEROIDS
STEROLS