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Effects of X-ray irradiation on natural killer (NK) cell system. I. Elevation of sensitivity of tumor cells and lytic function of NK cells

Journal Article · · Immunopharmacology and Immunotoxicology; (USA)
; ; ;  [1]
  1. Kyoto Univ. (Japan)
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The in vitro effect of X-ray irradiation on the human natural killer (NK) system was studied. When K562 cells were irradiated with X-rays and cultured for 18 hours, they showed increased sensitivity to lysis by blood lymphocytes and purified large granular lymphocytes (LGL). The X-ray-induced augmentation was observed as little as 2 Gy irradiation, reaching maximum at 5 to 20 Gy. The doses of X-rays did not influence the viability and spontaneous release of the target cells. On the other hand, irradiation with X-rays of NK cells at 5 to 15 Gy resulted in a transient increase in NK activity at 1 hour, and then the activity declined and was completely lost after 24 hours. However, when LGL were cultured with interferon immediately after irradiation, they maintained elevated NK activity. These results suggest the possible use of low doses of X-ray irradiation in combination with biological response modifiers for treatment of cancer.

OSTI ID:
6937414
Journal Information:
Immunopharmacology and Immunotoxicology; (USA), Journal Name: Immunopharmacology and Immunotoxicology; (USA) Vol. 11:2-3; ISSN 0892-3973; ISSN IITOE
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GROWTH FACTORS
INTERFERON
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LOW DOSE IRRADIATION
LYMPHOCYTES
LYMPHOKINES
LYSIS
MAMMALS
MAN
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
SOMATIC CELLS
TUMOR CELLS
VERTEBRATES
X RADIATION