The growth and development of Schistosoma mansoni in mice exposed to sublethal doses of radiation
- Univ. of York, Heslington (England)
The maturation of Schistosoma mansoni was studied in mice exposed to various sublethal doses of radiation. Although the treatment of mice with 500 rads of radiation prior to infection did not alter parasite maturation, doses in excess of 500 rads led to a reduction in worm burden. This could not be attributed to a delay in the arrival of parasites in the hepatic portal system. Worms developing in mice treated with 800 rads commenced egg-laying about 1 wk later than worms in intact mice, and the rate of egg deposition appeared to be lower in irradiated hosts. The data demonstrate that exposure of C57BL/6 mice to doses of radiation in excess of 500 rads impairs their ability to carry infections of S. mansoni. The findings do not support the hypothesis that primary worm burdens in the mouse are controlled by a host immune response.
- OSTI ID:
- 6936868
- Journal Information:
- Journal of Parasitology; (USA), Journal Name: Journal of Parasitology; (USA) Vol. 75:6; ISSN 0022-3395; ISSN JOPAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HELMINTHS
IMMUNITY
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
PARASITIC DISEASES
PLATYHELMINTHS
RADIATION DOSES
RADIATIONS
RADIOINDUCTION
RODENTS
SCHISTOSOMA
SCHISTOSOMIASIS
SUBLETHAL IRRADIATION
TREMATODES
VERTEBRATES
VIABILITY