Host sex-dependent growth of potential Thy-1+ lymphoma cells that appear in the thymus of X-irradiated NFS mice

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577572· OSTI ID:6936855

Mori, N; Takamori, Y ^[1]

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1. Osaka Prefectural Radiation Research Institute (Japan)

During the course of studies designed to detect potentially leukemic cells in radiation lymphomagenesis, using an opposite-sex (male----female) transplantation assay method, we previously found that potential Thy-1- lymphoma cells are generated in the bone marrow of NFS mice exposed to a split-dose irradiation (1.7 Gy X 4), while potential Thy-1+ lymphoma cells are not detectable. In this report, using a (female----male) intrathymic transplantation assay system we show that potential Thy-1+ lymphoma cells were generated in the thymus of female NFS mice exposed to split-dose irradiation, and reconfirm that such cells were not detected in the (male----female) transplantation system. These results demonstrate that the detection of potential Thy-1+ lymphoma cells strictly depends on the transplantation system.

• OSTI ID: 6936855
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 121:1; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
DISEASES
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
IMMUNE SYSTEM DISEASES
IRRADIATION
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MICE
NEOPLASMS
ORGANS
RADIOINDUCTION
RODENTS
SEX DEPENDENCE
THYMUS
TISSUES
TRANSPLANTS
TUMOR CELLS
VERTEBRATES