Genesis of Thy-1-lymphomas in NFS mice exposed to X irradiation
Journal Article
·
· Radiat. Res.; (United States)
The kinetics of the appearance of potentially leukemic cells (PoLCs) for radiation-induced lymphoma in NFS mice was investigated by the opposite sex (male----female) transplantation assay. The origin of the cells of the lymphomas that developed in the host was decided by sex chromosome markers. The bone marrow and the spleen cells collected from mice 30 days after fractionated irradiation (1.7 Gy X 4) gave rise, upon transfer to 4-Gy-irradiated hosts, to tumors of either donor or host origin. Most tumors of donor origin were thymine-1-negative (Thy-1-) and surface immunoglobulin negative and classified as nonthymic lymphoma, while the tumors of host origin were mainly Thy-1-positive thymic lymphoma. In contrast, neither the bone marrow nor the thymus contained any PoLCs for thymic lymphoma 30 days after split-dose irradiation. These results indicate that PoLCs for Thy-1-lymphoma were induced in the bone marrow and spleens of NFS mice by the split-dose regimen which developed exclusively T-cell lymphomas in the absence of cell grafting.
- Research Organization:
- Radiation Center of Osaka Prefecture, Osaka (Japan)
- OSTI ID:
- 6465847
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 117:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Host sex-dependent growth of potential Thy-1+ lymphoma cells that appear in the thymus of X-irradiated NFS mice
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Sun Dec 31 23:00:00 EST 1989
· Radiation Research; (USA)
·
OSTI ID:6936855
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Wed Jul 01 00:00:00 EDT 1987
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Journal Article
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Thu Sep 15 00:00:00 EDT 1988
· J. Immunol.; (United States)
·
OSTI ID:6557248
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IMMUNE SYSTEM DISEASES
IMMUNOASSAY
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
LYMPHOMAS
MAMMALS
MATERIALS
MICE
NEOPLASMS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IMMUNE SYSTEM DISEASES
IMMUNOASSAY
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
LYMPHOMAS
MAMMALS
MATERIALS
MICE
NEOPLASMS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES
X RADIATION