Endogenous type-C viral expression during lymphoma development in irradiated NFS mice

Journal Article · Fri Nov 01 04:00:00 EST 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576611· OSTI ID:5802578

Okumoto, M; Nishikawa, R; Takamori, Y; Iwai, Y; Iwai, M; Tsubura, Y

The expression of the type-C retrovirus and the virus-related components in NFS mice were examined during preleukemic and leukemic phases after fractionated whole-body X irradiation. The NFS mice were highly susceptible to induction of thymoma by fractionated X irradiation. The leukemic tissues were negative for infectious type-C virus, as detected by both the XC-plaque test and mink S+ L- focus-inducing assays, but contained a substantially higher level of viral-specific RNA-dependent DNA polymerase activity and a major core protein p30 than the corresponding tissues from unirradiated age-control mice. In the preleukemic phase, the amount of p30-related antigen increased transiently in spleen. The leukemic cell lines established from radiation-induced lymphomas produced particulate entities with a buoyant density of about 1.15 g/ml. These virus-like particles lacked in vitro infectivity to mouse cells and mink lung cells and leukemogenicity in syngeneic mice. The p30-related antigens of these particles were immunologically similar to that of xenotropic virus derived from NZB mouse.

• Research Organization: Radiation Center of Osaka Prefecture, Sakai, Japan
• OSTI ID: 5802578
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States); ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
DNA
DNA POLYMERASES
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
HEMIC DISEASES
INFECTIVITY
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
NUCLEIC ACIDS
NUCLEOTIDYLTRANSFERASES
ORGANIC COMPOUNDS
ORGANS
PARASITES
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
THYMUS
TRANSFERASES
VERTEBRATES
VIRUSES
WHOLE-BODY IRRADIATION
X RADIATION