Influence of caffeine on X-ray-induced killing and mutation in V79 cells

Journal Article · Sat Jan 31 23:00:00 EST 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576956· OSTI ID:6936599

Bhattacharjee, S B; Bhattacharyya, N; Chatterjee, S

Effects produced by caffeine on X-irradiated Chinese hamster V79 cells depended on the growth conditions of the cells. For exponentially growing cells, nontoxic concentrations of caffeine decreased the shoulder width from the survival curve, but the slope remained unchanged. The yield of mutants under the same conditions also remained unaffected. In case of density-inhibited cells, delaying trypsinization for 24 h after X irradiation increased the survival and decreased the yield of mutants. The presence of caffeine during this incubation period inhibited such recovery and significantly increased the yield of X-ray-induced mutants.

• Research Organization: Saha Institute of Nuclear Physics, Calcutta, India
• OSTI ID: 6936599
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANALEPTICS
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CAFFEINE
CELL KILLING
CENTRAL NERVOUS SYSTEM AGENTS
DNA REPAIR
DRUGS
HAMSTERS
HETEROCYCLIC COMPOUNDS
MAMMALS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
VERTEBRATES
XANTHINES