Selective use of palmitic acid over stearic acid for synthesis of phosphatidylcholine and phosphatidylglycerol in lung
The incorporation of (/sup 3/H)palmitic acid and (/sup 14/C)stearic acid into phospholipids in rabbit lung tissue was studied. Under equal molar concentrations of palmitate and stearate, palmitate was incorporated to the 1- and 2-positions of phosphatidylcholine (PC) and phosphatidylglycerol (PG) 2-3 times more than stearate. By contrast, palmitate was 30% less than stearate in phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine. These results suggest that preferential utilization of palmitate over stearate, rather than substrate availability, determines the high content of palmitoyl at the 1- and 2-positions of PC and PG in lung.
- Research Organization:
- Univ. of Wisconsin, Madison
- OSTI ID:
- 6935231
- Journal Information:
- Lipids; (United States), Journal Name: Lipids; (United States) Vol. 11; ISSN LPDSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOSYNTHESIS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
ESTERS
HEXADECANOIC ACID
IN VITRO
LABELLED COMPOUNDS
LIPIDS
LUNGS
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
OCTADECANOIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
RABBITS
RESPIRATORY SYSTEM
SYNTHESIS
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOSYNTHESIS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
ESTERS
HEXADECANOIC ACID
IN VITRO
LABELLED COMPOUNDS
LIPIDS
LUNGS
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
OCTADECANOIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
RABBITS
RESPIRATORY SYSTEM
SYNTHESIS
TRITIUM COMPOUNDS
VERTEBRATES