Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash

Journal Article · Wed Jan 01 04:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530886· OSTI ID:5088744

Srivastava, P K; Misra, U K

The effect of intratracheal administration of fly ash has been studied on lung microsomal and lung surfactant phosphatidylcholine (PC) metabolism in rats using (methyl-/sup 14/C)choline and (methyl-/sup 14/C)methionine. Fly-ash administration significantly increased total phospholipids, PC, phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) of lung surfactant. Fly-ash administration stimulated the formation of lung microsomal PC (as measured by the incorporation of labeled precursors) both by the cytidine 5'-diphosphate (CDP)-choline pathway and by the N-methylation pathway, but this stimulation was fourfold higher in the latter case and only twofold higher in the former as compared to the control. Likewise, the secretion of PC formed by the N-methylation pathway was sixfold higher as compared to the control whereas secretion of PC formed by the CDP-choline pathway was only threefold higher as compared to the control. Fly-ash administration further increased total saturation and decreased unsaturation in PC, PE, and lysophosphatidylcholine (LPC) of lung and in PC, PE, LPC, and PG of lung surfactant as compared to the controls.

• Research Organization: Univ. of Delhi, India
• OSTI ID: 5088744
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 18:3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ALCOHOLS
AMINES
AMINO ACIDS
AMMONIUM COMPOUNDS
ANIMALS
ASHES
BIOLOGICAL PATHWAYS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHOLINE
DATA
DRUGS
ESTERS
EXPERIMENTAL DATA
FLY ASH
HYDROXY COMPOUNDS
INFORMATION
INTRATRACHEAL ADMINISTRATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPIDS
LIPOTROPIC FACTORS
LUNGS
MAMMALS
METABOLISM
METHIONINE
MICROSOMES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHOLIPIDS
QUATERNARY COMPOUNDS
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SURFACTANTS
TOXICITY
TRACER TECHNIQUES
VERTEBRATES
WASTES