Turnover of phospholipids isolated from fractions of lung lavage fluid
Journal Article
·
· J. Appl. Physiol.; (United States)
OSTI ID:6335946
To clarify the steps following surfactant secretion, we injected adult rabbits with radioactive palmitate, lavaged the airways, removed the cells, separated by ultracentrifugation lavage components into two fractions (B and C), and followed the labeling of phospholipids of these fractions. The results were compatible with the view that total and saturated phosphatidylcholine are transferred from B to C. Furthermore, the fluxes of total and saturated phosphatidylcholine through fraction C (0.45 and 0.30 mumol . h-1 . g lung-1, respectively) were compatible with the actual estimates of surfactant recycling. The labeling of phosphatidylglycerol ruled out a simple precursor-product relationship between B and C but was compatible with a nonideal first-order relationship. The labeling of phosphatidylinositol, cardiolipin, and phosphatidylethanolamine was incompatible with the existence of a direct precursor-product relationship between B and C. The labeling of total and saturated phosphatidylcholine suggests that fraction B may be made by active surfactant, whereas fraction C may contain surfactant modified for reuptake or for reuptake and catabolism.
- Research Organization:
- Universita di Padova, Italy
- OSTI ID:
- 6335946
- Journal Information:
- J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 4; ISSN JAPYA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOLIPIN
CENTRIFUGATION
CHOLINE
DRUGS
ESTERS
GLYCEROL
HEXADECANOIC ACID
HYDROXY COMPOUNDS
INOSITOLS
IRRIGATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
LAVAGE
LIPIDS
LIPOTROPIC FACTORS
LUNGS
MAMMALS
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
PRECURSOR
QUATERNARY COMPOUNDS
RABBITS
RESPIRATORY SYSTEM
SACCHARIDES
SECRETION
SEPARATION PROCESSES
SURFACTANTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ULTRACENTRIFUGATION
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOLIPIN
CENTRIFUGATION
CHOLINE
DRUGS
ESTERS
GLYCEROL
HEXADECANOIC ACID
HYDROXY COMPOUNDS
INOSITOLS
IRRIGATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
LAVAGE
LIPIDS
LIPOTROPIC FACTORS
LUNGS
MAMMALS
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
PRECURSOR
QUATERNARY COMPOUNDS
RABBITS
RESPIRATORY SYSTEM
SACCHARIDES
SECRETION
SEPARATION PROCESSES
SURFACTANTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ULTRACENTRIFUGATION
VERTEBRATES