The influence of MDP on Ga-67 distribution in vivo
The purpose of this study was to determine the effect of methylene diphosphonate (MDP) on the uptake and distribution of Ga-67 in vivo. Previous studies have shown that some phosphorous containing compounds such as pyrophosphate compete with iron binding molecules for uptake of Ga-67. Because Tc-99m MDP is often used clinically in conjunction with Ga-67, it is important to know if MDP alters the distribution of gallium. 25 gm adult outbred female Swiss mice were injected I.V. with doses of MDP ranging from 0 to 1000 times the normal human dose on a per weight basis. Two hours later, each mouse was injected with 5 uCi of Ga-67 citrate, followed 24 hours later by sacrifice and dissection. Activity was recorded as percent injected dose per gram tissue weight. Distribution of Ga-67 in control vs. treated animals was compared using Student's t test to determine statistical significance of differences. At up to 100 times normal dose, the authors found no difference in the uptake of Ga-67 due to the MDP pre-treatment in the following organs: blood, heart, liver, muscle, bone, GI tract, spleen and kidney. At above 100 times normal dose, there was a statistically significant increase in the uptake of Ga-67 in the spleen and decrease in bone, while activity in muscle, kidney and GI tract varied with no clear dose relationship. The data suggest that the usual concentration of MDP used for bone scanning does not interfere with the biodistribution of Ga-67. Therefore, gallium scans which are preceded by Tc-99m MDP bone scans can be interpreted as if both scans had been performed separately.
- Research Organization:
- Yale Univ., New Haven, CT
- OSTI ID:
- 6933872
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Abnormal Tc-99m-MDP/GA-67 scan patterns in association with active chronic osteomyelitis
Comparative uptake of /sup 67/Ga and /sup 99m/Tc MDP in rabbits with a benign noninfected bone lesion (fracture)
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FEMALES
GALLIUM 67
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
IN VIVO
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
IRON
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHONATES
QUANTITY RATIO
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES