Effect of methylene diphosphonate on the tissue distribution of gallium-67

Journal Article · Tue Oct 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6290146

Downing, D; Aburano, T; Bushberg, J; Hoffer, P B

Nonradiolabeled methylene diphosphonate (MDP) was administered intravenously to CFW Swiss outbred female mice 2 hr prior to i.v. injection of (WXGa)citrate. The dose of MDP ranged from that usually administered for bone scanning (17.9 micrograms/kg) to 1,000 times the usual bone scan dose (17.9 mg/kg). The animals were killed 24 hr after administration of (WXGa)citrate and organ distribution determined as compared to control animals who received no MDP. At MDP doses one to ten times usual bone scan dose, the only organ showing significantly different WXGa uptake was the lung and this difference in pulmonary uptake was accounted for by incidental pulmonary infection. At MDP doses 100 to 1,000 times usual bone scan dose, significantly altered WXGa uptake was noted in lung, spleen, kidney, and gastrointestinal tract. The only consistent pattern of association of MDP administered dose and alteration in WXGa uptake, however, was noted in the spleen where uptake was augmented with increased dose, and the bone where increased MDP dose depressed WXGa uptake. Even this effect, however, was modest. It is concluded that at usual MDP dose levels used in bone imaging, no significant alterations occur in WXGa distribution in normal mouse tissue. It is inferred that WXGa scans performed following bone scans can be interpreted as if both radiopharmaceuticals had been administered separately.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT
• OSTI ID: 6290146
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACID SALTS
CITRATES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
GALLIUM 67
GALLIUM ISOTOPES
GASTROINTESTINAL TRACT
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LUNGS
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHONIC ACID ESTERS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
RODENTS
SPLEEN
TISSUE DISTRIBUTION
VERTEBRATES