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Validation of a rotating camera based SPECT system for dosimetry applications

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6933285
; ; ;
The authors have evaluated the quantitative properties of a rotating camera based SPECT system using three isotopes commonly used clinically (Tc-99m, In-111, and I-123 contaminated with I-124). The isotopes were chosen due to their different imaging characteristics. The Alderson body phantom was used with 'hot' spheres, with and without background activity, to determine system sensitivity and linearity. An analytic post processing attenuation correction routine was implemented which increased system linearity with respect to position in the phantom and was used throughout the study. Up to four organ phantoms were placed in the body phantom and imaged in two ways. First, a two view planar technique, and second, a circular rotation SPECT acquisition. The two view planar technique uses a combination arithmetic and geometric mean with correction for attenuation. The planar technique showed good correlation to actual activity in absence of background (slope .98; R .99), and slightly degraded accuracy with background (slope .91; R .97). However, it was only able to quantitate activity when no overlying or underlying organs were present. The SPECT system, though, was clearly able to distinguish regions of activity in transverse section for which accurate quantitation was possible. Very good correlation between SPECT activity and measured activity was observed both with (slope .98; R .98), and without (slope 1.02; R .99) background activity present. Accurate quantitation of total organ activity is very useful not only for dosimetry applications, but also for radiotherapy planning and monitoring of treatment.
Research Organization:
Univ. of Massachusetts Medical Center, Worcester, MA
OSTI ID:
6933285
Report Number(s):
CONF-840619-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ATTENUATION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CAMERAS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 124
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
MOCKUP
MONITORING
MOTION
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PHANTOMS
PLANNING
POSITIONING
PROCESSING
QUANTITY RATIO
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
ROTATION
SENSITIVITY ANALYSIS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STRUCTURAL MODELS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TESTING
THERAPY
TOMOGRAPHY
TRACER TECHNIQUES
VALIDATION
YEARS LIVING RADIOISOTOPES