Quantitative small field-of-view pinhole SPECT imaging: Initial evaluation

Journal Article · Tue Aug 01 04:00:00 EDT 1995 · IEEE Transactions on Nuclear Science

DOI:https://doi.org/10.1109/23.467740· OSTI ID:148056

Li, J; Jaszczak, R J; Coleman, R E ^[1]

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1. Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology

A quantitative filtered back projection (FBP) algorithm for small field-of-view pinhole SPECT has been implemented and evaluated. This algorithm compensates for attenuation, scatter, geometric collimator response and system misalignment. Pinhole SPECT quantification with three different pinhole collimators was evaluated using experimentally acquired phantom data. SPECT scans using both in-air and in-water point sources located at different places and a cylinder filled with uniform activity were acquired. Planar scans of an in-air point source from different incident angles were acquired to determine the angular dependence of the geometric collimator response. Images were reconstructed using the FBP algorithm, with geometric response correction, dual-window scatter subtraction (c = 0.4), single iteration Chang attenuation compensation, and system misalignment correction. Total activities in point source experiments and concentrations in cylindrical phantom experiments were measured. Accurate quantitative results (<7%) were obtained using the pinhole FBP algorithm.

• OSTI ID: 148056
• Report Number(s): CONF-941061--
• Journal Information: IEEE Transactions on Nuclear Science, Journal Name: IEEE Transactions on Nuclear Science Journal Issue: 4Pt1 Vol. 42; ISSN 0018-9499; ISSN IETNAE
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ALGORITHMS
IMAGE PROCESSING
PHANTOMS
SCATTERING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY