Pinhole SPECT for imaging In-111 in the head
- Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
With the development of targeted radiotherapy techniques, quantitation of radionuclides that emit high-energy photons (>140 keV) by gamma camera scintigraphy has become increasingly important in external imaging applications. The radionuclide In-111 (171 and 245 keV) has been used experimentally with monoclonal antibodies and receptor specific pharmaceuticals to obtain pre-treatment information for various types of brain tumors. Conventional protocols for imaging In-111 utilize parallel-hole collimators designed for medium energy (ME) applications. The performance of ME collimators suffers from decreased spatial resolution and/or sensitivity. Septal penetration can also lead to image degradation. Pinhole collimation can offer improved spatial resolution and/or sensitivity compared with ME collimators when imaging In-111 in objects the size of the head or smaller, especially when restricting the field-of-view to regions near the central plane. Simulation and experimental phantom studies have been used to investigate pinhole SPECT for imaging In-111 in the head. Chang attenuation and dual-window scatter subtraction compensation methods have been evaluated for potential accuracy in pinhole geometry. Results have shown improved image quality with pinhole collimation with a {<=}15% quantitative accuracy in phantom studies. The authors demonstrate that pinhole SPECT is a viable alternative to ME collimator imaging of In-111 in objects the size of the head.
- OSTI ID:
- 148059
- Report Number(s):
- CONF-941061--
- Journal Information:
- IEEE Transactions on Nuclear Science, Journal Name: IEEE Transactions on Nuclear Science Journal Issue: 4Pt1 Vol. 42; ISSN 0018-9499; ISSN IETNAE
- Country of Publication:
- United States
- Language:
- English
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