Which collimator for SPECT with I-123 and CU-67
Cu-67 has been suggested for use in radioimmunoimaging and radioimmunotherapy because of its suitable photon energy for imaging (185 keV, 47%) and optimum beta emissions for therapy (0.577 keV, 20%; 0.484 keV, 35%; 0.395 keV, 45%). I-123 has been used in radioimmunoimaging and other procedures. Phantom resolution with I-123 (p,5n) appears comparable to that of Tc-99m using the usual low energy collimators. However, photons of energy greater than 200 keV are also emitted by these radionuclides with relative abundances of 1.3% for Cu-67 and 2.4% for I-123 (p,5n). Collimator septal penetration is a much larger fraction of the photopeak counts and causes degraded uniformity on transverse section images. The authors have examined the performance of 2 low, one medium (300 keV) and one high energy (364 keV) commercially available collimators using Cu-67 or I-123 in a SPECT phantom. The gamma ray spectra, SPECT sensitivity, spatial resolution and uniformity performance were assessed for a rotating gamma camera system. The low energy collimators gave transverse section images with serious nonuniformity artifacts and no possibility of applying an attenuation compensation algorithm. The 300 keV collimator produced better images for I-123 although the performance was degraded relative to Tc-99m and the low energy collimators. However, the 'cold' defect resolution showed little difference between collimators and radionuclides. The authors conclude that the 300 keV collimator represents the better compromise for SPECT tomography with either I-123 (p,5n) or Cu-67.
- Research Organization:
- Univ. of California Davis Medical Center, Sacramento, CA
- OSTI ID:
- 6931204
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BARYON REACTIONS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CAMERAS
CHARGED-PARTICLE REACTIONS
COLLIMATORS
COMPUTERIZED TOMOGRAPHY
COPPER 67
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTARY PARTICLES
EMISSION COMPUTED TOMOGRAPHY
ENERGY RANGE
FERMIONS
GAMMA CAMERAS
GAMMA SPECTRA
HADRON REACTIONS
HADRONS
HOURS LIVING RADIOISOTOPES
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KEV RANGE
KEV RANGE 100-1000
MASSLESS PARTICLES
MEDICINE
MOCKUP
NEUTRONS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUCLEONS
ODD-EVEN NUCLEI
PHANTOMS
PHOTONS
PROTON REACTIONS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RESOLUTION
SENSITIVITY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SPATIAL RESOLUTION
SPECTRA
STRUCTURAL MODELS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPEUTIC USES
THERAPY
TOMOGRAPHY
TRACER TECHNIQUES
USES
YEARS LIVING RADIOISOTOPES