Evaluation of a nuclease-resistant derivative of poly(i) poly(c) (poly(iclc)) as a radioprotective agent 1, 2. Interim report
Technical Report
·
OSTI ID:6929886
The synthetic double-stranded ribonucleic acid, polyriboinosinic acid polyribocytidylic acid (poly(I) poly(C)) is an interferon inducer, has antiviral and antitumor properties, and has been shown to be radioprotective in rodents. The observation that the radioprotective action of poly(I) poly(C), as well as certain endotoxins and chemicals, may be associated with their ability to induce interferon, has also stimulated interest in the possible radioprotective action of interferon itself.
- Research Organization:
- Army Medical Research Inst. of Infectious Diseases, Frederick, MD (USA)
- OSTI ID:
- 6929886
- Report Number(s):
- AD-A-051580
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BLOOD SERUM
CELLULOSE ESTERS
COBALT
DOSES
DRUGS
ELEMENTS
ENZYMES
ESTERS
EXTERNAL IRRADIATION
INTERFERON
IRRADIATION
MAMMALS
METALS
NUCLEASES
ORGANIC COMPOUNDS
PHOSPHOTRANSFERASES
RADIATION DOSES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RESPONSE MODIFYING FACTORS
RODENTS
TRANSFERASES
TRANSITION ELEMENTS
VERTEBRATES
WHOLE-BODY IRRADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BLOOD SERUM
CELLULOSE ESTERS
COBALT
DOSES
DRUGS
ELEMENTS
ENZYMES
ESTERS
EXTERNAL IRRADIATION
INTERFERON
IRRADIATION
MAMMALS
METALS
NUCLEASES
ORGANIC COMPOUNDS
PHOSPHOTRANSFERASES
RADIATION DOSES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RESPONSE MODIFYING FACTORS
RODENTS
TRANSFERASES
TRANSITION ELEMENTS
VERTEBRATES
WHOLE-BODY IRRADIATION