Evaluaion of a nuclease-resistant derivative of poly(I) poly(C) (poly(ICLC)) as a radioprotective agent. [Whole-body. gamma. -irradiated mice]

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575139· OSTI ID:6210048

Baze, W B ^[1]; Lvovsky, E; Higbee, G A; Levy, H B; Hilmas, D E

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1. Army Medical Research Inst. of Infectious Diseases, Fort Detrick, MD

Intramuscular injection of a stabilized polyriboinosinic acid-polyribocytidylie acid complex, composed of the two acids poly-l-lysine and carboxymethylcellulose (poly(ICLC)), was radioprotective in mice when given in single or multiple doses before total-body irradiation. At low to moderately high dosages, LD/sub 50/30/ values were increased significantly (P < 0.05), with a maximum dose-reduction factor of 1.25. Survival rates and weighted mean survival times were also significantly increased. Increased circulating levels of serum interferon proportional to poly (ICLC) concentration were not required at the time of irradiation for radioprotection. Poly (ICLC) was found to have a slight stimulatory effect on the numbers of peripheral blood elements in irradiated mice.

• OSTI ID: 6210048
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 77:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
CYTIDYLIC ACID
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
INFORMATION
INJECTION
INOSINE
INTAKE
INTERFERON
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAMUSCULAR INJECTION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LETHAL IRRADIATION
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PURINES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RIBOSIDES
RODENTS
SURVIVAL TIME
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES