Synthesis and radioprotective activity of new cysteamine and cystamine derivatives

Journal Article · Sat Nov 01 00:00:00 EST 1986 · J. Med. Chem.; (United States)

DOI:https://doi.org/10.1021/jm00161a015· OSTI ID:6927085

Oiry, J; Pue, J Y; Imbach, J L; Fatome, M; Sentenac-Roumanou, H; Lion, C

A variety of N-(aminoalkanoyl)-S-acylcysteamine and N,N'-bis(aminoalkanoyl)cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S-acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N-glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structure-activity relationships are discussed.

• Research Organization: Universite des Sciences et Techniques du Languedoc, Montpellier, France
• OSTI ID: 6927085
• Journal Information: J. Med. Chem.; (United States), Vol. 11
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CYSTAMINE
RADIOSENSITIVITY EFFECTS
MEA
MICE
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TOXICITY
AMINES
ANIMALS
DRUGS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
RODENTS
THIOLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
560152 - Radiation Effects on Animals- Animals